肱动脉内皮依赖性舒张功能鉴别左室舒张功能假性正常化的价值

目的:研究冠心病患者左室舒张功能假性正常化与肱动脉内皮依赖性舒张功能的关系。方法:将75例行选择性冠状动脉造影的患者按冠状动脉病变程度分为单/双支病变组和三支病变组两组,选取48例健康志愿者作为对照组。检测左室舒张功能指标二尖瓣口血流频谱E峰、A峰、E/A比值,同时观察休息时肱动脉反应性充血后内径变化率。结果:单/双支病变组(第一组)E峰、E/A比值下降,肱动脉反应性充血后内径变化率低于正常对照组(P<0.05);三支病变组(第二组)E峰、E/A值无明显改变,肱动脉反应性充血后内径变化率明显低于对照组(P<0.01)。结论:肱动脉内皮依赖性舒张功能可作为鉴别冠心病左室舒张功能假性正常的指标。

Value of Endothelium-dependent Dilation of the Brachial Artery in Differentiating False Normalization of Left Ventricular Diastolic Function

Objective:To study the relation of false normalization of left ventricular diastolic function and endothelium-dependent dilation of the brachial artery in patients with coronary artery disease(CAD).Methods:75 patients undergoing a selective coronary an- giography were divided into 2 groups according to severity of coronary artery stenosis.Group one was mono-branch and bi-branch coro- nary artery stenosis,and group two was tri-branch coronary artery stenosis.And 48 normal subjects were as the control group.The pa- rameters of diastole early period velocity(E),diastole later period velocity(A)and E/A were detected.At the same time the EDD of the brachial arteries was measured respectively before and after reactive hyperemia.Results:In group one,E velocity and E/A ratio were de- creased,and the inner diameter changes of the brachial artery were lower than the control group(P<0.05).For group two,E velocity and E/A ratio were normal,but the inner diameter changes of the brachial artery were much lower than controls(P<0.01).Conclusion:The EDD of the brachial artery can differentiate false normalization of left ventricular diastolic function.