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Adaptor protein self-assembly drives the control of a cullin-RING ubiquitin ligase

Authors:	Errington Wesley J Khan M Qasim Bueler Stephanie A Rubinstein John L Chakrabartty Avijit Privé Gilbert G

Institution:	Department of Biochemistry, University of Toronto, 1 Kings College Circle, Toronto, Ontario M5S 1A8, Canada.

Abstract:	Download : Download high-res image (188KB) Download : Download full-size image Highlights? The crystal structure of the heterotetrameric CRL3-SPOP ubiquitin ligase is reported ? Substrate adaptor proteins are recruited to CRL complexes through a signature motif ? Tandem BTB and BACK domains potentiate assembly and activity of the CRL3-SPOP ligase ? The SPOPL negative regulator creates a molecular rheostat to fine-tune CRL3 activity

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