A possible role for calmodulin in Ca2+-induced swelling of mitochondria |
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| Authors: | O Hatase T Itano H Matsui A Doi S Etoh H Nishio S Nakahara |
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| Institution: | Dept. of Physiology, Kagawa Medical School, Japan. |
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| Abstract: | Ca2+-induced mitochondrial swelling was inhibited by a low concentration of calmodulin antagonists. Two affinities of Ca2+ to mitochondrial swelling were observed: high (2-5 microM) and low (more than 100 microM) systems. The high-affinity change was inhibited by micromolar level of trifluoperazine and W-7, but not by W-5. The possible mechanism of this inhibition and the role of CaM in mitochondria are discussed. |
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