A case of congenital toxoplasmosis-associated miscarriage with maternal infection four months prior to conception |
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| Institution: | 1. Department of Obstetrics, State University of Rio de Janeiro, Rio de Janeiro, Brazil;2. Department of Gynecology and Obstetrics, Serra dos Órgãos University Center, Teresópolis, Brazil;3. Department of Epidemiology, State University of Rio de Janeiro, Rio de Janeiro, Brazil;4. Department of Epidemiology, National School of Public Health (Fiocruz), Rio de Janeiro, Brazil;5. Department of Gynecology and Obstetrics, Unigranrio University, Rio de Janeiro, Brazil;6. Department of Gynecology and Obstetrics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil;7. Department of Radiology, Clínica de Diagnóstico por Imagem, Rio de Janeiro, Brazil;8. Department of Obstetrics, Paulista School of Medicine—Federal University of São Paulo, São Paulo, Brazil;9. Municipal University of São Caetano do Sul, Campus Bela Vista, São Paulo, Brazil;1. Laboratoire de Parasitologie-Mycologie, Centre Hospitalier Universitaire de Grenoble Alpes, CS 10217, 38043 Grenoble cedex 9, France;2. Institute for Advanced Biosciences, Team Host-Pathogen interactions and immunity to infection, INSERM U1209, CNRS UMR5309, Université Grenoble Alpes, 38700 Grenoble, France;3. Laboratoire de Parasitologie-Mycologie, Centre National de Référence Toxoplasmose, Centre Hospitalier Universitaire de Reims, 45 rue Cognacq-Jay, 51092 Reims, France;4. EA 3800, UFR Médecine, SFR CAP-SANTE, Université Reims Champagne Ardenne, 51092 Reims, France;5. Service de Pédiatrie, Centre Hospitalier de Voiron, 14 Route des Gorges, 38500 Voiron, France |
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| Abstract: | BackgroundWe report a case of fatal congenital toxoplasmosis with maternal infection dated four months before pregnancy in the absence of any specific immunosuppressive condition.CaseMs. D. experienced submaxillary lymphadenitis in February 2018. The medical workup performed revealed an acute T. gondii infection. She became pregnant in June 2018 while she still had adenopathy. The second obstetrical ultrasound, performed at 16 weeks of pregnancy, revealed a fetal death. The research for T. gondii by PCR was positive in the products of conception.ConclusionDiagnosis of toxoplasmosis should be discussed in case of miscarriage with lymphadenitis. As lymph nodes in T. gondii infection could be responsible for iterative release of parasites and fetal death, symptomatic toxoplasmosis should be treated in women of childbearing age. |
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