Novel insights into the biopharmaceutical potential,comparative phytochemical analysis and multivariate analysis of different extracts of shea butter tree -Vitellaria paradoxa C. F. Gaertn |
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| Institution: | 1. Department of Biology, Science Faculty, Selcuk University, Campus, Konya, Turkey;2. University of Rijeka, Department of Biotechnology, Centre for High-Throughput Technologies, Radmile Matejčić 2, 51000, Rijeka, Croatia;3. Laboratoire de Botanique, UFR Biosciences, Université Félix Houphouët-Boigny, Abidjan, Cote d’Ivoire;4. Institute of Research and Development, Duy Tan University, Da Nang, 550000, Viet Nam;5. University of Mauritius, Faculty of Science, Department of Health Sciences, Réduit, Mauritius;1. Department of Pharmacy, University of Chieti–Pescara “G. d’Annunzio”, Chieti, Italy;2. Department of Genetics and Bioengineering, Faculty of Engineering and Architecture, Kastamonu University, Kastamonu, Turkey;3. Department of Biology, Selcuk University, Science Faculty, Konya, Turkey;4. Department of Health Sciences, Faculty of Science, University of Mauritius, Réduit, Mauritius;1. Microbial Drugs Laboratory, Department of Studies in Microbiology, Manasagangotri, University of Mysore, Mysore, 570006, Karnataka, India;2. Department of Microbiology, Yuvaraja’s College (Autonomous), University of Mysore, Mysuru, 570 005, Karnataka, India;3. Department of Biochemistry, Indian Institute of Science, Bengaluru, 560 012, Karnataka, India;1. Food College, Shihezi University, Shihezi 832000, Xinjiang Uygur Autonomous Region, PR China;2. College of Information Science and Technology, Shihezi University, Shihezi 832000, Xinjiang Uygur Autonomous Region, PR China;1. Ultrasonography Department, People’s Hospital of Rongcheng, Rongcheng, 264300, China;2. Department of Gynecology, the First People''s Hospital of Jining City 272000, China;3. Department of Gynecology, Binzhou Hospital of Traditional Chinese Medicine, Binzhou, 256600, China;4. Ultrasonography Department, Linyi People''s Hospital, Linyi, 276000, China;1. Department of obstetrics, The Second Affiliated Hospital of Xi''an Medical University, China;2. Department of Nursing, The Second Affiliated Hospital of Xi''an Medical University, China |
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| Abstract: | Vitellaria paradoxa C. F. Gaertn. (Family: Sapotaceae), is a well-known medicinal plant but with no consolidated published literature to substantiate its traditional uses. This research aimed to investigate the pharmaceutical potential of V. paradoxa extracts and attempts to compare the biological profiles and phytochemical analysis prepared by different extraction protocols. For preparation of the V. paradoxa leaves and stem bark extracts, four extraction techniques and two different solvent types were employed. First analysis included identification of bioactive compounds by use of high-resolution Quadrupole Time-Of-Flight instrument. Antioxidant capacities were evaluated as radical scavenging potential, reducing potential, total antioxidant capacity (phosphomolybdenum) and metal chelating power. The last evaluation step included analysis of the inhibitory properties of V. paradoxa extracts against key enzymes related to main health problems. Our findings revealed key details on phytochemical profiling of the V. paradoxa plant, whereas 17 phytochemicals were identified in leaves and 14 in stem bark. Antioxidant assays showed that extracts obtained by maceration extraction process exhibit potent antioxidant capacities. Extracts prepared by HAE generally showed the highest enzymatic activities. The presented findings confirmed the need for further studies geared towards discovery and development of novel bioactive components from V. paradoxa leaves and stem bark. |
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| Keywords: | Antioxidants Phytochemicals Enzyme inhibitors Extraction methods |
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