Unveiling the anticancer and antimycobacterial potentials of bioengineered gold nanoparticles |
| |
| Institution: | 1. Department of Marine and Coastal Studies, School of Energy, Environment and Natural Resources, Madurai Kamaraj University, Madurai 625 021, Tamil Nadu, India;2. Laboratorio de Nanocelulosa y Biomateriales, Departamento de Ingeniería Química, Biotecnología y Materiales, Facultad de Ciencias Físicas y Matemáticas, Universidad de Chile, Avenida Beauchef 851, Santiago, Chile;3. Department of Microbial Technology, School of Biological Sciences, Madurai Kamaraj University, Madurai 625 021, Tamil Nadu, India;4. Department of Biotechnology, Maharishi Markendeswar University, Mullana-Ambala 133-207, Haryana, Inida;1. Department of Biochemistry, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran;2. Department of Materials Science and Engineering, Faculty of Engineering, Shahid Bahonar University of Kerman, Kerman, Iran;3. Department of Chemistry, Faculty of Sciences, University of Sistan and Baluchestan, Zahedan, Iran |
| |
| Abstract: | Synthesis of gold nanoparticles was carried out using Pongammia pinnata (pongam) leaf extract and their anticancer and antimycobacterial activities were studied. Gold nanoparticle formation was confirmed by UV–vis, XRD and HR-TEM. The anticancer efficacies of the biogenic gold nanoparticles were analyzed using cytotoxicity, cell morphology analysis, oxidative DNA damage, apoptosis detection and toxicity studies. Biogenic gold nanoparticles inhibited breast cancer cell line (MCF-7) proliferation with an efficacy of IC50 of 1.85 μg/mL. The antimycobacterial potential of the biogenic gold nanoparticles was screened against M. tuberculosis by Luciferase Reporter Phage (LRP) assay. The gold nanoparticles showed inhibition against sensitive M. tuberculosis with the minimum inhibitory concentration (MIC) of 10 μg/mL whereas no inhibition was found against the rifampicin resistant M. tuberculosis. |
| |
| Keywords: | Gold nanoparticles Anticancer Toxicity Antimycobacterial activity |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
