Emerging strategies for expanding the toolbox of enzymes in biocatalysis |
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Institution: | 1. Department of Biochemistry, Faculty of Science, Kasetsart University, Chatuchak, Bangkok, Thailand;2. Department of Biotechnology, Faculty of Engineering and Industrial Technology, Silpakorn University, Nakhon Pathom, Thailand;3. School of Biomolecular Science and Engineering, Vidyasirimedhi Institute of Science and Technology (VISTEC), Wangchan Valley, Rayong, Thailand;1. Faculty of Chemistry, Bielefeld University, Universitätsstraße 25, 33615 Bielefeld, Germany |
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Abstract: | Expanding the repertoire of reactions available to enzymes is an enduring challenge in biocatalysis. Owing to the synthetic versatility of transition metals, metalloenzymes have been favored targets for achieving new catalytic functions. Although less well explored, enzymes lacking metal centers can also be effective catalysts for non-natural reactions, providing access to reaction modalities that compliment those available to metals. By understanding how these activation modes can reveal new functions, strategies can be developed to access novel biocatalytic reactions. This review will cover discoveries in the last two years which access catalytic reactions that go beyond the native repertoire of metal-free biocatalysts. |
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