Biogenesis of the peptide-derived redox cofactor pyrroloquinoline quinone |
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| Affiliation: | 1. California Institute for Quantitative Biosciences and Department of Chemistry, University of California, Berkeley, CA, 94720-3220, USA;2. Department of Molecular and Cell Biology, University of California, Berkeley, CA, 94720-3220, USA |
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| Abstract: | Pyrroloquinoline quinone (PQQ) is a peptide-derived redox cofactor produced by prokaryotes that also plays beneficial roles in organisms from other kingdoms. We review recent developments on the pathway of PQQ biogenesis, focusing on the mechanisms of PqqE, PqqF/G, and PqqB. These advances may shed light on other, uncharacterized biosynthetic pathways. |
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| Keywords: | PQQ Cofactor Biosynthesis PqqA Peptide PqqD PqqE Radical SAM enzyme PqqF PqqG Peptidase PqqB Nonheme iron-dependent hydroxylase PqqC Cofactorless oxidase |
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