Unravelling the insulin-like growth factor I-mediated photoprotection of the skin |
| |
| Affiliation: | 1. Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha 410078, China;2. Hunan Key Lab of Mineral Materials and Application, Central South University, Changsha 410083, China;3. School of Minerals Processing and Bioengineering, Central South University, Changsha 410083, China;4. Institute of Chemical Biology and Nanomedicine, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China |
| |
| Abstract: | Chronic exposure of human skin to solar ultraviolet radiation (UVR) induces a range of biological reactions which may directly or indirectly lead to the development of skin cancer. In order to overcome these damaging effects of UVR and to reduce photodamage, the skin’s endogenous defence system functions in concert with the various exogenous photoprotectors. Growth factors, particularly insulin-like growth factor-I (IGF-I), produced within the body as a result of cellular interaction in response to UVR demonstrates photoprotective properties in human skin. This review summarises the impact of UVR-induced photolesions on human skin, discusses various endogenous as well as exogenous approaches of photoprotection described to date and explains how IGF-I mediates UVR photoprotective responses at the cellular and mitochondrial level. Further, we describe the current interventions using growth factors and propose how the knowledge of the IGF-I photoprotection signalling cascades may direct the development of improved UVR protection and remedial strategies. |
| |
| Keywords: | Photobiology Keratinocytes UVB radiation Insulin-like growth factors Photodamage Photoprotection |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
