Hepatoprotective effect of pyrroloquinoline quinone against alcoholic liver injury through activating Nrf2-mediated antioxidant and inhibiting TLR4-mediated inflammation responses |
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| Institution: | 1. Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, China;2. Qianjiang College, Hangzhou Normal University, Hangzhou 310012, China;3. College of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, China;4. ECA Healthcare Inc, Shanghai 201101, China;1. National Engineering Laboratory for Tree Breeding, College of Biological Sciences and Biotechnology, Beijing Forestry University, Beijing 100083, China;2. School of Nature Conservation, Beijing Forestry University, Beijing 100083, China;1. Izmir Biomedicine and Genome Center, 35340, İzmir, Turkey;2. Department of Chemistry, The Graduate School of Natural and Applied Sciences, Dokuz Eylul University, 35390, İzmir, Turkey;3. Izmir International Biomedicine and Genome Institute, Dokuz Eylul University, 35340, İzmir, Turkey;4. Department of Chemistry, Division of Biochemistry, Faculty of Science, Dokuz Eylul University, 35390, İzmir, Turkey;1. Stem Cell and Tissue Engineering Laboratory, Dalian University of Technology, 116024 Dalian, China;2. School of Life Science and Medicine, Dalian University of Technology, Panjin Campus, 124221 Panjin, China;3. Department of Engineering Science, Oxford University, OX1 3PJ Oxford, UK;1. Department of Pharmacology and Toxicology, German Universiy in Cairo, Egypt;2. Institute for Stroke and Dementia Research (ISD), Klinikum der Universität München, Germany;3. Department of Biochemistry, German University in Cairo, Egypt;1. NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu, 214063, China;2. Department of Radiopharmaceuticals, School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu, 211166, China |
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| Abstract: | The present study was aimed at investigating the hepatoprotective effect of pyrroloquinoline quinone (PQQ) against acute alcoholic liver injury in mice. Acute alcoholic liver injury model was established in mice, and they were administrated with PQQ to investigate its hepatoprotective effect. Our results shows that PQQ can significantly ameliorate acute alcoholic liver injury by decreasing the hepatic marker enzymes, including serum alanine transaminase (ALT) and aspartate transaminase (AST), and increasing the levels of alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) in the liver. And PQQ can also significantly reduce the content of hepatic triglyceride (TG) and malondialdehyde (MDA). Moreover, PQQ attenuated alcohol-induced oxidative damage by activating NF-E2-related factor 2 (Nrf2)-mediated signaling pathway, and inhibiting Toll-like receptor 4 (TLR4)-mediated nuclear factor-kappa B (NF-κB) signaling pathway. Our findings have elucidated the liver protection mechanism of PQQ, which would encourage the further exploitation of PQQ as a hepatoprotective functional food. |
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| Keywords: | Pyrroloquinoline quinone Alcoholic liver injury Oxidative stress Nrf2 signal pathway NF-κB signal pathway |
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