Novel fabrication of morphology tailored nanostructures with Gelatin/Chitosan Co-polymeric bio-composited hydrogel system to accelerate bone fracture healing and hard tissue nursing care management |
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| Affiliation: | 1. First Department of Orthopedics, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, PR China;2. Fourth Department of Orthopedics, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, PR China;3. Department of Emergency, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, PR China;4. Third Department of Orthopedics, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, PR China;5. Second Department of Orthopedics, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, PR China;1. School of Food Science, Northeast Agricultural University, Harbin 150030, China;2. School of Information Science and Technology, Peking University, Beijing 100871, China;3. School of Computer and Information Engineering, Harbin University of Commerce, Harbin 150028, China;1. Basic Sciences Laboratory, Faculty of Dentistry, Autonomous University of San Luis Potosi, 78290 SLP, Mexico;2. Department of Wood, Cellulose and Paper Research, University of Guadalajara, 45110 Guadalajara, Mexico;3. Wallenberg Wood Science Center, SE-412 96 Göteborg, Sweden;1. Environmental Simulation and Pollution Control State Key Joint Laboratory, School of Environment, Tsinghua University, Beijing 100084, China;2. Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, PR China;3. Central Research Institute of Building and Construction, MCC Group, Co, Ltd;1. Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Nanjing Forestry University, Nanjing, 210037, People’s Republic of China;2. College of Chemical Engineering, Nanjing Forestry University, Nanjing, 210037, People’s Republic of China;3. Jiangsu Province Key Laboratory of Green Biomass-based Fuels and Chemicals, Nanjing, 210037, People’s Republic of China;1. Department of Physics, College of Education for Pure Sciences, University of Babylon, Iraq;2. Department of Electric Power Engineering, Ministry of Electricity, Iraq;3. Department of Engineering, Faculty of Electrical Engineering, University Malaysia Perlis, Arau, Jalan Wang, 01000 Kangar Perlis, Malaysia |
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| Abstract: | In this study, we are successfully fabricated on a hydrogel consisting of TiO2 nanoparticles loaded onto a gelatin/chitosan matrix to control the acceleration of bone fracture healing and improved the nursing care applications. Each specimen (chitosan, gelatin and titanium dioxide) were characterized and confirmed by using different techniques, Fourier transforms infrared spectroscopy, X-ray diffraction analysis, Scanning Electron Microscopy with Elemental dispersive X-ray analysis, Thermo-gravimetric and Differential thermal analysis. In addition, the cell cytotoxicity results verified that the TiO2/gelatin-chitosan hydrogel are nontoxic to osteoblasts. And cell fixation outcome after 5 days of incubation condition revels that the enhanced in vitro cell survival and cell spreading on the prepared TiO2 incorporated hydrogel with respect to gelatin/chitosan hydrogel. Furthermore, TiO2/gelatin-chitosan hydrogel nanostructures can modulate the bone fracture healing, indicating a potential application on nursing care. |
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| Keywords: | Gelatin Chitosan Hydrogel Bone fracture healing Nursing care |
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