Targeted and proteome-wide analysis of metabolite–protein interactions |
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| Institution: | 1. CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China;2. State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China;3. University of Chinese Academy of Sciences, Beijing 100049, China;3. Department Willmitzer, Max Planck Institute for Molecular Plant Physiology, 14476 Potsdam;4. MetaSysX GmbH, 14476 Potsdam, Germany;1. Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390-8816, USA;2. Laboratory of Chemical Biology and Microbial Pathogenesis, The Rockefeller University, New York, NY 10065, USA |
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| Abstract: | Understanding the molecular mechanisms of endogenous and environmental metabolites is crucial for basic biology and drug discovery. With the genome, proteome, and metabolome of many organisms being readily available, researchers now have the opportunity to dissect how key metabolites regulate complex cellular pathways in vivo. Nonetheless, characterizing the specific and functional protein targets of key metabolites associated with specific cellular phenotypes remains a major challenge. Innovations in chemical biology are now poised to address this fundamental limitation in physiology and disease. In this review, we highlight recent advances in chemoproteomics for targeted and proteome-wide analysis of metabolite–protein interactions that have enabled the discovery of unpredicted metabolite–protein interactions and facilitated the development of new small molecule therapeutics. |
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| Keywords: | Chemical reporter Metabolite Proteomics |
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