Synthesis and characteristics of new fluorescent probes based on cardiolipin |
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| Authors: | I. A. Boldyrev Yu. B. Pavlova Jul. G. Molotkovsky |
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| Affiliation: | (1) Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia |
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| Abstract: | New fluorescent lipid probes, cardiolipin derivatives AV12-CL and B7-CL, bearing the residues of 12-(9-anthryl)-11E-dodecenoic and 7-(4,4-difluoro-1,3,5,7-tetramethyl-4-bora-3a,4a-diaza-s-indacen-8-yl)heptanoic acid, respectively, have been synthesized by acylation of 1-lysocardiolipin, which had been obtained from bovine heart cardiolipin by enzymatic hydrolysis with bacterial lipase. The resulting probes are intended for the study of protein-anionic phospholipid interactions. |
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| Keywords: | anthrylvinyl BODIPY cardiolipin fluorescent lipid probes synthesis |
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