Effect of tamoxifen on the activity of enzymes of testicular steroidogenesis |
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| Authors: | H Vanderstichele W Eechaute E Lacroix I Leusen |
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| Institution: | Laboratory of Normal and Pathological Physiology, University of Ghent, Belgium. |
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| Abstract: | Testicular homogenates of tamoxifen-treated rats were incubated with labeled steroid precursors (progesterone, 17 alpha-hydroxyprogesterone, dehydroepiandrosterone, androstenedione or testosterone) in order to study the effect of tamoxifen on testicular steroidogenesis. The results indicate that a 9 day treatment with a daily dose of 1 mg tamoxifen produces a reduction of the synthesis of testosterone. Inhibition of the 17 alpha-hydroxylase and C17,20-desmolase enzyme systems was observed together with an increased 20 alpha-hydroxysteroid dehydrogenase activity. |
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