Mechanisms of TonB-catalyzed iron transport through the enteric bacterial cell envelope |
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| Authors: | Phillip E Klebba Jeanette M Rutz Jun Liu Christopher K Murphy |
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| Institution: | (1) Department of Microbiology, Medical College of Wisconsin, 8701 Watertown Plank Rd., 53226 Milwaukee, Wisconsin;(2) Biophysics Research Institute, Medical College of Wisconsin, 8701 Watertown Plank Rd., 53226 Milwaukee, Wisconsin;(3) Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Ave., 02115 Boston, Massachusetts;(4) Unite de Programmation Moleculair & Toxicologie Genetique, Institut Pastèur, 75015 Paris, France |
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| Abstract: | The recent solution of enteric bacterial porin structure, and new insights into the mechanism by which outer membrane receptor proteins recognize and internalize specific ligands, advocates the re-evaluation of TonB-dependent transport physiology. In this minireview we discuss the potential structural features of siderophore receptors and TonB, and use this analysis to evaluate both existing and new models of energy and signal transduction from the inner membrane to the outer membrane of gram-negative bacteria. |
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| Keywords: | TonB iron transport bacterial transport |
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