Significantly increased fractions of transformed to total alpha2-macroglobulin concentrations in plasma from patients with multiple sclerosis |
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Authors: | Jensen Poul Erik H Humle Jørgensen Signe Datta Pameli Sørensen Per Soelberg |
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Institution: | The Neuroimmunology Laboratory, Section 9302, MS Research Unit, Copenhagen University Hospital, Juliane Mariesvej 20, 2100 Copenhagen, Denmark. pejensen@nru.dk |
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Abstract: | We examined the proteinase inhibitor alpha2-macroglobulin (alpha2M) in plasma from patients with multiple sclerosis (MS); a neurological disease of the central nervous system. The plasma concentrations of native and transformed alpha2M were measured in 90 patients with clinically definite MS, 73 with relapsing-remitting and 17 with secondary progressive MS, and 132 healthy individuals. Significantly lower concentrations of native alpha2M and significantly higher concentrations of transformed alpha2M were found in MS patients. A significant correlation between the concentrations of native and transformed alpha2M was found. The fraction of transformed to total alpha2M in the MS patients was 36% higher than in the healthy individuals. The results suggest an important involvement of alpha2M in regulation of increased proteolytic activity occurring in MS disease. |
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