脂蛋白脂酶基因多态性与2 型糖尿病的相关性研究

目的：探讨脂蛋白脂酶（lipoprotein lipase，LPL）基因PvuⅡ酶切多态性与2型糖尿病的相关性。方法：采用聚合酶链反应-限制性片段长度多态性（PGR-RFLP）方法，分析了156例样本LPL基因第6内含子PvuⅡ多态性（病例组98人。对照组58。其中40个2型糖尿病同胞对，病例组40人，对照组40人）。结果：病例组与对照组的基因型和基因频率均无显著性差异。结论：湖北汉族人群脂蛋白脂酶基因PvuⅡ酶切多态性与2型糖尿病无明显关联。

Association research of lipoprotein lipase gene polymorphismand type 2 diabetes mellitus

Objective: To study the relationship between the lipoprotein lipase gene Pvuò polymorphism and type 2 diabetes meill-itus. Methods: PCR- RFLP method was used to determine the Pvuò polymorphism of intron 6 in LPL gene in 156 samples[ compatriot group( n= 80) : case group( n= 40) and control group( n= 40) ; randomly selected group( n= 76) : case group( n= 58) and control group( n= 18) ] .Results: Therewere no significant differences in the genotype and gene frequency between cases and controls. Conclusion: The Pvuò polymorphismof LPL gene is not associated with type 2 diabetes mellitus in Hubei Han people.