Structure-based design of protein tyrosine phosphatase-1B inhibitors |
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| Authors: | Black Emma Breed Jason Breeze Alexander L Embrey Kevin Garcia Robert Gero Thomas W Godfrey Linda Kenny Peter W Morley Andrew D Minshull Claire A Pannifer Andrew D Read Jon Rees Amanda Russell Daniel J Toader Dorin Tucker Julie |
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| Institution: | AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK. |
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| Abstract: | Using structure-based design, a new class of inhibitors of protein tyrosine phosphatase-1B (PTP1B) has been identified, which incorporate the 1,2,5-thiadiazolidin-3-one-1,1-dioxide template. |
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