MicroRNA precursors in motion: exportin-5 mediates their nuclear export |
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| Authors: | Kim V Narry |
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| Affiliation: | School of Biological Sciences and Institute of Molecular Biology and Genetics, Seoul National University, Korea. narrykim@snu.ac.kr |
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| Abstract: | The discovery of microRNSs (miRNAs) has changed the paradigm of gene regulation, leaving us with numerous exciting questions regarding what these molecules do and how they originate. A model for miRNA biogenesis has emerged recently, yet several key factors--including the identity of the miRNA nuclear export receptor--remained unknown. However, recent studies have shown that exportin-5 (Exp5), a Ran-dependent importin-beta-related transport receptor, mediates nuclear export of miRNA precursors (pre-miRNAs). |
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