Identification of a PstI polymorphism in the p21Cip1/Waf1 cyclin-dependent kinase inhibitor gene |
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| Authors: | John C. Law Anee Deka |
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| Affiliation: | (1) Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, 15261 Pittsburgh, PA, USA |
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| Abstract: | A PstI polymorphism in the 3 flanking region of the p21CiP1/Waf1 cyclin-dependent kinase inhibitor gene is described. DNA sequencing analysis identified a C T base substitution in the 3 flanking region of the gene. This substitution leads to the destruction of a PstI site and results in a biallelic DNA polymorphism. This restriction fragment length polymorphism (RFLP) provides the first known genetic marker for this cell cycle regulatory gene. |
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