Structure of tau protein and assembly into paired helical filaments |
| |
| Authors: | Friedhoff P von Bergen M Mandelkow E M Mandelkow E |
| |
| Affiliation: | Max-Planck-Unit for Structural Molecular Biology, Hamburg, Germany. |
| |
| Abstract: | Over the past few years the systematic investigation of paired helical filament assembly from tau protein in vitro has become feasible. We review our current understanding of the structure and conformations of tau protein and how this affects tau's assembly into the pathological paired helical filaments in Alzheimer's disease. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
