Effects of L-carnitine on urea synthesis following acute ammonia intoxication in mice |
| |
Authors: | M Costell J E O'Connor M P Míguez S Grisolía |
| |
Institution: | 1. Department of Biochemistry, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto 602, Japan;2. National Cancer Center Research Institute, Chuo-ku, Tokyo 104, Japan |
| |
Abstract: | L-Carnitine protects mice against acute ammonia intoxication. The effect of L-carnitine on in vivo incorporation of 14C] bicarbonate into urea has been investigated in mice given large doses of ammonium acetate. The hepatic content of N-acetylglutamate has been measured. Following ammonia administration the animals given L-carnitine have much higher production of urea than the unprotected mice. The marked protective effect of L-carnitine on ammonium acetate-induced hyperammonemia and on the increase in urea synthesis is not due primarily to activation of N-acetylglutamate synthetase. |
| |
Keywords: | W-7 N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide TPA 12-0-tetradecanoylphorbol-13-acetate |
本文献已被 ScienceDirect PubMed 等数据库收录! |