Inhibitory effect of galanin on pancreatic polypeptide release by the perfused rat pancreas期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Inhibitory effect of galanin on pancreatic polypeptide release by the perfused rat pancreas

Authors:	R A Silvestre P Miralles L Monge M L Villanueva J Marco

Institution:	1. Department of Physiology, Nanjing University of Chinese Medicine Hanlin College, Taizhou 225300, China;2. Department of Endocrinology, Clinical Medical College, Yangzhou University, Yangzhou 225001, China;3. Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Medical College, Yangzhou University, Yangzhou 225001, China;1. Key Laboratory for Metabolic Diseases in Chinese Medicine & Hanlin College, Nanjing University of Chinese Medicine, Nanjing 210023, China;2. Department of Endocrinology, Pukou Branch of Jiangsu People''s Hospital, Nanjing 211899, China;3. Department of Endocrinology, Clinical Medical College, Yangzhou University, Yangzhou 225001, China

Abstract:	We have investigated the effect of galanin infusion on unstimulated pancreatic polypeptide (PP) release as well as on the PP response to arginine by the perfused rat pancreas. Galanin significantly reduced unstimulated PP output. Addition of arginine to the perfusate evoked a biphasic pattern of PP release; the second phase of this PP response was delayed when galanin was simultaneously infused. These findings point to a regulatory role of galanin in the control of PP secretion.

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