Modulation of red cell K transport by membrane lipids |
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Authors: | M. Poznansky D. Kirkwood A.K. Solomon |
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Affiliation: | Biophysical Laboratory, Harvard Medical School, Boston, Mass. 02115 U.S.A. |
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Abstract: | Alterations in the state of the membrane lipids affect human red cell K+ transport. Depletion of membrane cholesterol by 29–34% significantly inhibited both total K+ influx and ouabain-sensitive K+ influx. Addition of the hydrophobic anesthetic, chlorpromazine, in concentration from 2 · 10−5 to 2 · 10−4 M increased both total K+ influx and ouabain-sensitive K+ influx. In each case the effect on both processes was almost identical which indicates a linkage between K+ “pump” and “leak”. Further, these results demonstrate that red cell K+ transport can be modulated by local conditions in the micro-environment of the transport system. |
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