Electrostatic interactions in gramicidin channels |
| |
Authors: | G. Martinez M. Sancho |
| |
Affiliation: | (1) Facultad de Fisica, Departamento de Fisica Aplicada III, Universidad Complutense, E-28040 Madrid, Spain |
| |
Abstract: | A model based on the solution of the electrostatic potential for a geometry of three dielectric regions associated with a gramicidin A channel (GA) is presented. The model includes a cylindrical dielectric layer to represent the peptide backbone and dipole rings to account for dipolar side chains. Image potential and dipolar contributions for different orientations and positions along the channel are analyzed. The conductance of GA and two analogues obtained by substituting the amino acid at position 1 are studied. The numerical simulation reproduces experimental results (Barrett et al. 1986, Biophys J 49, 673–686) and supports the idea that electrostatic dipole-ion interactions are of primary importance in gramicidin channel function.Correspondence to: G. Martinez |
| |
Keywords: | Ion-channel interaction Gramicidin Electrostatic model Channel conductance Residue substitution |
本文献已被 SpringerLink 等数据库收录! |
|