27-Nor-triterpenoid glycosides from Mitragyna inermis |
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Authors: | Cheng Zhi-Hong Yu Bo-Yang Yang Xiu-Wei |
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Affiliation: | Department of Complex Presection of CMM, China Pharmaceutical University, 210038, Nanjing, People's Republic of China. |
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Abstract: | From the bark of Mitragyna inermis, two 27-nor-triterpenoid glycosides, named inermiside I (1) and II (2), were isolated and their structures determined based on extensive 2D-NMR and MS spectral analysis as 6-deoxy-beta-D-glucopyranosyl-[3-O-beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranosyl]-pyrocincholate and 6-deoxy-beta-D-glucopyranosyl-pyrocincholate, respectively. In addition, the known quinovic acid (6), 3-O-[beta-D-glucopyranosyl-(1-->4)-alpha-L-rhamnopyranosyl]-quinovoic acid (3),beta-D-glucopyranosyl-[3-O-(beta-D-glucopyranosyl)]-quinoviate (4) and cytotoxic 3-O-(beta-D-6-deoxy-glucopyranosyl)-quinovic acid (5) were also isolated. |
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Keywords: | Mitragyna inermis Rubiaceae Pyrocincholic acid Quinovic acid Triterpenoid saponins Cytotoxic activity |
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