Genetic analysis of acetan biosynthesis in Acetobacter xylinum: DNA sequence analysis of the aceM gene encoding an UDP-glucose dehydrogenase |
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| Authors: | Annette M. Griffin Kirstin J. Edwards Victor J. Morris Michael J. Gasson |
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| Affiliation: | (1) Norwich Laboratory, Institute of Food Research, Norwich Research Park, Colney Norwich, NR4 7UA, UK |
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| Abstract: | Analysis of the nucleotide sequence of a 1592 bp region of Acetobacter xylinum genomic DNA involved in acetan biosynthesis revealed the presence of an open-reading frame (aceM) encoding a protein of 449 amino acids with a molecular weight of 48.5 kDa. The deduced amino acid sequence of aceM displayed high homology to the protein sequences of genes encoding UDP-glucose dehydrogenase (UGDH) activities from other organisms. AceM is likely to encode the UGDH involved in the biosynthesis of UDP-glucuronic acid required for acetanbiosynthesis. This revised version was published online in November 2006 with corrections to the Cover Date. |
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