Resveratrol metabolites in urine as a biomarker of wine intake in free-living subjects: The PREDIMED Study |
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| Authors: | Raul Zamora-Ros Mireia Urpí-Sardà Rosa M Lamuela-Raventós Ramon Estruch Miguel Ángel Martínez-González Mònica Bulló Fernando Arós Antonio Cherubini Cristina Andres-Lacueva |
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| Institution: | 1. Cardiology Department, Villa Bianca Hospital Trento, Italy;2. Heart Failure Clinic, Division of Cardiology/C.C.U. San Camillo Hospital, Rome, Italy;3. Cardiovascular Center, Health Authority no. 1 and University of Trieste, Italy;4. Cardiology Department, St. Martino Hospital Azienda Sanitaria Locale n. 1, Belluno, Italy;5. Department of Cardiocirculatory Diseases, San Giovanni-Addolorata Hospital, Rome, Italy;6. Cardiovascular Department, Ospedali Riuniti, Bergamo, Italy;1. Biomarkers & Nutrimetabolomic Lab, Nutrition and Food Science Department, XaRTA, INSA, Campus Torribera, Pharmacy Faculty, University of Barcelona, Barcelona 08028, Spain;2. Department of Biological Sciences & Department of Computing Science, University of Alberta, Edmonton, AB, Canada T6G 2E9;3. Dept. ESAII, Technical University of Catalonia (UPC), Barcelona, Spain;4. Unitat de RMN, Centres Científics i Tecnològics, Universitat de Barcelona, Baldiri Reixac, 10-12, 08028 Barcelona, Spain;5. Servicio de Endocrinología y Nutrición, Hospital Universitario Virgen de la Victoria, IBIMA, University of Málaga, Spain |
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| Abstract: | Several clinical and epidemiological studies have shown that moderate wine consumption may exert a protective effect against oxidative stress involved in several diseases, such as cardiovascular and neurodegenerative disorders. However, the epidemiological assessment of wine consumption has usually been obtained using self-reported questionnaires containing less reliable information for assessing total intake than nutritional biomarkers. A reliable biomarker for wine consumption is, therefore, needed. To validate urinary resveratrol metabolites (RMs) as a biomarker of wine consumption in a large cohort of free-living subjects, 1000 consecutive subjects entering a substudy of the PREDIMED trial (Prevención con Dieta Mediterránea) were evaluated. Data were collected in a validated semiquantitative food frequency questionnaire. RMs were measured in morning urine by LC-MS/MS. Urinary RM values correlated directly with reported daily amounts of wine consumed (r = 0.895; p < 0.001). One drink of wine per week can be detected. Using a cut-off of 411.4 nmol/g creatinine, the measurement of urinary RMs could discriminate wine consumers from non-wine consumers with a sensitivity of 93.3% (95% confidence interval (CI) 91.5–94.7%) and a specificity of 92.1% (CI 90.2–93.7%). Urinary RMs fulfill the criteria to be considered as a nutritional biomarker of wine consumption in a large sample of free-living subjects. This biomarker would provide an additional tool for investigating more precisely the relationship between wine consumption and health benefits. |
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