Association of a polymorphism of the apolipoprotein E gene with chronic kidney disease in Japanese individuals with metabolic syndrome |
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| Authors: | Tetsuro Yoshida Kimihiko Kato Tetsuo Fujimaki Kiyoshi Yokoi Mitsutoshi Oguri Sachiro Watanabe Norifumi Metoki Hidemi Yoshida Kei Satoh Yukitoshi Aoyagi Yutaka Nishigaki Masashi Tanaka Yoshinori Nozawa Yoshiji Yamada |
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| Affiliation: | 1. Department of Cardiovascular Medicine, Inabe General Hospital, Inabe, Japan;2. Department of Cardiovascular Medicine, Gifu Prefectural Tajimi Hospital, Tajimi, Japan;3. Department of Cardiology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan;4. Department of Cardiology, Gifu Prefectural General Medical Center, Gifu, Japan;5. Department of Internal Medicine, Hirosaki Stroke Center, Hirosaki, Japan;6. Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki, Japan;7. Department of Genomics for Longevity and Health, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan;8. Gifu International Institute of Biotechnology, Kakamigahara, Japan;9. Department of Human Functional Genomics, Life Science Research Center, Mie University, 1577 Kurima-machiya, Tsu, Mie 514-8507, Japan |
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| Abstract: | The purpose of the present study was to identify genetic variants that confer susceptibility to chronic kidney disease (CKD) in Japanese individuals with metabolic syndrome. The study population comprised 2150 Japanese individuals with metabolic syndrome, including 411 subjects with CKD [estimated glomerular filtration rate (eGFR) < 50 mL/min/1.73m2] and 1739 controls (eGFR ≥ 60 mL/min/1.73m2). The genotypes for 100 polymorphisms of 80 candidate genes were determined. The chi-square test, multivariable logistic regression analysis with adjustment for covariates, as well as a stepwise forward selection procedure revealed that nine polymorphisms of APOE, ABCA1, PTGS1, TNF, CPB2, AGTR1, OR13G1, and GNB3 were associated (P < 0.05) with the prevalence of CKD. Among these polymorphisms, the ? 219G → T polymorphism of APOE (rs405509) was most significantly associated with CKD in Japanese individuals with metabolic syndrome. |
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