The genetic control of the immune response to murine histocompatibility antigens |
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Authors: | Peter J Wettstein Geoffrey Haughton |
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Institution: | (1) Genetics Curriculum, Department of Bacteriology and Immunology, University of North Carolina, 27514 Chapel Hill, North Carolina |
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Abstract: | The genetic control of the immune response to H-4 histocompatibility alloantigens is described. The rejection of H-4.2-incompatible skin grafts is regulated by anH-2-linkedIr gene. Fast responsiveness is determined by a dominant allele at theIrH-4.2 locus. TheH-2
b
,H-2
d
, andH-2
s
haplotypes share the fast response allele;H-2
a
has the slow response allele. Through the use of intra-H-2 recombinants, we have mapped theIrH-4.2 locus to theI-B subregion of theH-2 complex; theH-2
h4
,H-2
15, andH-2
t4
haplotypes are fast responder haplotypes. These observations suggest that the strength of non-H-2 histocompatibility antigens is ultimately determined by the antigen-specific recipient responsiveness. |
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Keywords: | |
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