中国肝细胞癌患者TACE术后死亡原因分析(英文)

目的:通过探讨中国肝细胞癌患者肝动脉化疗栓塞术(TACE)术后并发症及死亡原因,来提高临床治疗效果,并积累治疗经验。方法:通过联合检索CBM及CNKI上从1994年1月到2008年9月的关于中国肝细胞癌患者行TACE术后出现并发症的相关文章,分析总结肝细胞癌患者TACE术后死亡的原因及特点。结果:中国肝细胞癌患者TACE术后并发症较为危重,致死率较高,死亡原因有84%是肝功能衰竭、上消化道出血及肝癌破裂出血,且死亡病例发生在术后1月内的占78.7%,因此大多是早期死亡。结论:中国肝细胞患者TACE术后死亡原因主要是肝功能衰竭、上消化道出血及肝癌破裂出血,且术后死亡常为早期死亡,因此TACE术后严重并发症可直接影响患者的预后情况,我们需要提高对TACE术选择时机的重视程度,规范介入治疗手段和流程,尽量避免和减少严重并发症的发生。

Complications of Transcatheter Hepatic Arterial Chemoembolization (TACE)in Chinese Hepatocellular Carcinoma Patients RunningTitle: TACE-associated Mortality in China

Objective:To discuss the complications related to TACE in Chinese patients so as to increase the clinical effect and togain more experience.Methods:We retrieved articles fromJanuary 1994 to September 2008 in Chinese Medical Current Content (CBM)and National Knowledge Infrastructure (CNKI). Meta-analysis was performed on the results of homogeneous studies. All calculations forthe current meta-analysis were performed using REVIEWMANAGER 4.2.Results:There were 150 reported cases of deaths after TACE,among which hepatic failure, upper gastrointestinal bleeding and ruptured liver cancer with hemorrhage occurred in 84% of cases, and78.7% survived less than one month after operation.Conclusion:The primary etiology of death following TACE is acute liver failure,upper gastrointestinal bleeding and ruptured liver cancer with hemorrhage. The majority of peri-procedure fatalities are less than 30 daysfollowing TACE.