Impaired Glucose Tolerance in Sleep Disorders |
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Authors: | Marietta Keckeis Zuzana Lattova Eszter Maurovich-Horvat Pierre A Beitinger Steffen Birkmann Christoph J Lauer Thomas C Wetter Johanna Wilde-Frenz Thomas Pollm?cher |
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Institution: | 1. Max Planck Institute of Psychiatry, Munich, Germany.; 2. Klinikum Ingolstadt, Centre of Mental Health, Ingolstadt, Germany.;The Mental Health Research Institute of Victoria, Australia |
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Abstract: | BackgroundRecent epidemiological and experimental data suggest a negative influence of shortened or disturbed night sleep on glucose tolerance. Due to the high prevalence of sleep disorders this might be a major health issue. However, no comparative studies of carbohydrate metabolism have been conducted in clinical sleep disorders.Methodology/Principal FindingsWe performed oral glucose tolerance tests (OGTT) and assessed additional parameters of carbohydrate metabolism in patients suffering from obstructive sleep apnea syndrome (OSAS, N = 25), restless legs syndrome (RLS, N = 18) or primary insomnia (N = 21), and in healthy controls (N = 33). Compared to controls, increased rates of impaired glucose tolerance were found in OSAS (OR: 4.9) and RLS (OR: 4.7) patients, but not in primary insomnia patients (OR: 1.6). In addition, HbA1c values were significantly increased in the same two patient groups. Significant positive correlations were found between 2-h plasma glucose values measured during the OGTT and the apnea-arousal-index in OSAS (r = 0.56; p<0.05) and the periodic leg movement-arousal-index in RLS (r = 0.56, p<0.05), respectively. Sleep duration and other quantitative aspects of sleep were similar between patient groups.Conclusions/SignificanceOur findings suggest that some, but not all sleep disorders considerably compromise glucose metabolism. Repeated arousals during sleep might be a pivotal causative factor deserving further experimental investigations to reveal potential novel targets for the prevention of metabolic diseases. |
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