Inhibitory effect of extracts from Brazilian medicinal plants on the adhesion of Candida albicans to buccal epithelial cells |
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| Authors: | Susana Johann Daniele L. Silva Cleide V. B. Martins Carlos L. Zani Moacir G. Pizzolatti Maria A. Resende |
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| Affiliation: | 1.Departamento de Microbiologia, Instituto de Ciências Biológicas,Universidade Federal de Minas Gerais,Belo Horizonte,Brazil;2.Laboratório de Química de Produtos Naturais,Centro de Pesquisa René Rachou, Fiocruz,Belo Horizonte,Brazil;3.Centro de Engenharias e Ciências Exatas,Universidade Estadual do Oeste do Paraná,Toledo,Brazil;4.Departamento de Química,Universidade Federal de Santa Catarina,Florianopolis,Brazil |
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| Abstract: | Plants are known to produce a plethora of secondary metabolites which are recognized as a useful source of new drugs or drug leads. Extracts and fractions of Schinus terebinthifolius Raddi (Anacardiaceae), Piper regnellii C.D.C. (Piperaceae), Rumex acetosa L. (Polygonaceae), and Punica granatum L. (Punicaceae) were assessed for their antifungal activity against eight clinical isolates of C. albicans. They were also evaluated for their effect on the adhesion of these C. albicans isolates to buccal epithelial cells (BECs). The ethyl acetate fraction from the leaves of S. terebinthifolius showed promising activity, inhibiting the growth of three C. albicans isolates at 7.8 μg ml−1 and significantly inhibiting their adhesion to BEC at 15 μg ml−1 . In addition, this fraction did not show cytotoxic activity against murine macrophages. The results show the potential of the plant extracts studied as a source of new antifungal compounds. Further studies are necessary for isolation and characterization of the active compounds of these plants. |
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| Keywords: | Anti-adhesion Antifungal Buccal epithelial cells Cytotoxic activity Punica granatum Schinus terebinthifolius |
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