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Psilostachyin, acetylated pseudoguaianolides and their analogues: preparation and evaluation of their anti-inflammatory potential |
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| Authors: | Chib Renu Shah Bhahwal Ali Anand Naveen Pandey Anjali Kapoor Kamini Bani Sarang Gupta Vivek K Rajnikant Sethi Vijay K Taneja Subhash Chandra |
| Affiliation: | a Natural Product Microbes Division, Indian Institute of Integrative Medicine, Canal Road, Jammu 180 001, J&K, India b X-ray Crystallography Laboratory, Post-Graduate Department of Physics, University of Jammu, Jammu, Tawi 180 006, India |
| Abstract: | Naturally occurring acetylated pseudoguaianolides and psilostachyin including their analogues were synthesized. The structure of semi-synthetic psilostachyin was also confirmed by X-ray crystallography. The anti-inflammatory potential of all the derivatives has been evaluated through in vitro expression of TNF-α, IL-1β and IL-6 in murine neutrophils. |
| Keywords: | Acetylated pseudoguaianolides Psilostachyin Parthenin Anti-inflammatory |
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