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Discovery and SAR of 2-arylbenzotriazoles and 2-arylindazoles as potential treatments for Duchenne muscular dystrophy |
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| Authors: | De Moor Olivier Dorgan Colin R Johnson Peter D Lambert Adam G Lecci Cristina Maillol Carole Nugent Gary Poignant Séverine D Price Paul D Pye Richard J Storer Richard Tinsley Jonathon M Vickers Richard Well Renate van Wilkes Fraser J Wilson Francis X Wren Stephen P Wynne Graham M |
| Institution: | Summit plc., 91 Milton Park, Abingdon, Oxfordshire OX14 4RY, United Kingdom |
| Abstract: | Families of 2-arylbenzotriazoles and 2-arylindazoles that show positive effects in screens predictive of endogenous utrophin upregulation have been identified. Synthesis and structure-activity relationships are described leading to compounds with attractive in vitro profiles. |
| Keywords: | Duchenne Muscular Dystrophy Benzotriazole Indazole |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |