| 组织型转谷氨酰胺酶与肾脏纤维化 |
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| 作者姓名： | Liu SY Huang HC Li XM |
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| 作者单位： | 北京大学第一医院肾内科暨北京大学肾脏病研究所,北京,100034 |
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| 基金项目： | 国家自然科学基金重点项目资助课题(30330710) |
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| 摘 要： | 组织型转谷氨酰胺酶(tTG)是一个Ca2 依赖的具有转酰胺基作用的酶,它分布广泛,在许多生理和病理条件下发挥重要作用。近年来它参与组织纤维化的作用逐渐引起重视。tTG分泌到细胞外能够使很多细胞外基质蛋白成分之间发生交联,形成牢固结构,抵抗降解,从而促使细胞外基质沉积,促进组织纤维化发展。本文简要叙述tTG的分子特征和生理及病理学意义,并着重介绍tTG和肾脏纤维化的联系。
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| 关 键 词： | 组织型转谷氨酰胺酶 肾脏纤维化 细胞外基质 |
Tissue transglutaminase and renal fibrosis |
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| Liu SY,Huang HC,Li XM.Tissue transglutaminase and renal fibrosis[J].Progress in Physiological Sciences,2005,36(4):314-318. |
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| Authors: | Liu Sen-Yan Huang Hai-Chang Li Xiao-Mei |
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| Institution: | Renal Division, Department of Medicine, First Hospital and Institute of Nephrology, Peking University, Beijing 100034 |
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| Abstract: | Tissue transglutaminase(tTG),an enzyme which can catalyze the posttranslational modification of proteins,is widely distributed and plays an important role in both physiological and pathological processes.More recently,tissue transglutaminase has been believed to participate in tissue fibrosis.Cross-linked extracellular matrix proteins by tissue transglutaminase are stable and highly resistant to proteolytic degradation,thus lead to accumulation of the ECM proteins in tissue fibrosis.This review summarizes the important features of this multifunctional enzyme and particularly introduces the correlation between tTG and renal fibrosis. |
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| Keywords: | Tissue transglutaminase Renal fibrosis Extracellular matrix |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ |
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