In vivo acetylation of homocholine and beta-methylcholine in rat brain |
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Authors: | R M Dick J J Freeman J W Kosh |
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Institution: | Department of Basic Pharmaceutical Sciences College of Pharmacy University of South Carolina Columbia, S.C. 29208, USA |
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Abstract: | A nitrogen phosphorus-gas chromatographic procedure was modified to determine the extent of in vivo acetylation of the choline analogs homocholine and beta-methylcholine. Infusion of homocholine (18 mumoles) for 2 hours into the lateral ventricle of the rat produced 2.3 nmoles/gram of acetylhomocholine which represented 0.035% of the detected homocholine. Infusion of the same quantity of beta-methylcholine produced 1.0 nmole/gram of acetyl-beta-methylcholine representing 0.025% of the detected beta-methylcholine. Although pretreatment with hemicholinium-3 reduced the amount of acetylated product formed from either analog, the reduction was significant only for acetyl-beta-methylcholine (p less than 0.01). |
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