The coalescent and infinite-site model of a small multigene family |
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Authors: | Innan Hideki |
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Institution: | Department of Biological Science, University of Southern California, Los Angeles, California 90089-1340, USA. hinnan@sph.uth.tmc.edu |
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Abstract: | The infinite-site model of a small multigene family with two duplicated genes is studied. The expectations of the amounts of nucleotide variation within and between two genes and linkage disequilibrium are obtained, and a coalescent-based method for simulating patterns of polymorphism in a small multigene family is developed. The pattern of DNA variation is much more complicated than that in a single-copy gene, which can be simulated by the standard coalescent. Using the coalescent simulation of duplicated genes, the applicability of statistical tests of neutrality to multigene families is considered. |
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