The zipper mechanism in phagocytosis: energetic requirements and variability in phagocytic cup shape |
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| Authors: | Sylvain Tollis Anna E Dart George Tzircotis Robert G Endres |
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| Affiliation: | 1.Division of Molecular Biosciences,South Kensington Campus, Imperial College London,London,UK;2.Centre for Integrative Systems Biology at Imperial College (CISBIC), South Kensington Campus, Imperial College London,London,UK;3.Division of Cell and Molecular Biology,South Kensington Campus, Imperial College London,London,UK |
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| Abstract: | Background Phagocytosis is the fundamental cellular process by which eukaryotic cells bind and engulf particles by their cell membrane. Particle engulfment involves particle recognition by cell-surface receptors, signaling and remodeling of the actin cytoskeleton to guide the membrane around the particle in a zipper-like fashion. Despite the signaling complexity, phagocytosis also depends strongly on biophysical parameters, such as particle shape, and the need for actin-driven force generation remains poorly understood. |
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