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Polymorphisms in glutathione S-transferase M1 and T1 (GSTM1 and GSTT1) genes in the indigenous and the nonresident population of the Kemerovo region |
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| Authors: | V R Akhmatyanova A V Ostaptseva A V Shabaldin A N Glushkov V G Druzhinin V I Minina Y A Savchenko O A Glushkova M V Ulyanova Yu I Khripko M I Philipenko |
| Institution: | (1) Kemerovo State University, Kemerovo, 650043, Russia;(2) Institute of Human Ecology, Russian Academy of Sciences, Siberian Branch, Kemerovo, 650000, Russia;(3) Institute of Chemical Biology and Fundamental Medicine, Russian Academy of Sciences, Siberian Branch, Kemerovo, 630090, Russia |
| Abstract: | GSTM1 and GSTT1 gene polymorphisms were studied in Shorians, Teleuts, and Caucasians of the Kemerovo region. It has been shown that distribution of homozygous deletions in the examined groups is significantly heterogeneous. The frequency of deletion genotypes and combinations of deletion in these genes was lower in Shorians and, Teleuts than in Caucasians. |
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