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Molecular dynamics study with mutation shows that N-terminal domain structural re-orientation in Niemann-Pick type C1 is required for proper alignment of cholesterol transport |
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| Authors: | Hye-Jin Yoon Jian Jeong Hyung Ho Lee Soonmin Jang |
| Affiliation: | 1. Department of Chemistry, Seoul National University, Seoul, Republic of Korea;2. Department of Chemistry, Sejong University, Seoul, Republic of Korea |
| Abstract: | |
| Keywords: | cholesterol trafficking COVID-19 molecular dynamics simulation neurodegenerative Niemann-Pick C disease NPC1 NPC2 R518W mutant |