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Neuronal mechanisms of adenosine A2A receptors in the loss of consciousness induced by propofol general anesthesia with functional magnetic resonance imaging
Authors:Lei Chen  Shuang Li  Ying Zhou  Taotao Liu  Aoling Cai  Zongze Zhang  Fuqiang Xu  Anne Manyande  Jie Wang  Mian Peng
Institution:1. Department of Anesthesiology, Zhongnan Hospital of Wuhan University, Wuhan, P.R. China

Center of Brain Science, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Key Laboratory of Magnetic Resonance in Biological Systems, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan, China;2. Center of Brain Science, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Key Laboratory of Magnetic Resonance in Biological Systems, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan, China;3. Department of Anesthesiology, Zhongnan Hospital of Wuhan University, Wuhan, P.R. China;4. Department of Anesthesiology, Peking University Third Hospital, Beijing, China;5. Center of Brain Science, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Key Laboratory of Magnetic Resonance in Biological Systems, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan, China

University of Chinese Academy of Sciences, Beijing, PR China;6. Center of Brain Science, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Key Laboratory of Magnetic Resonance in Biological Systems, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan, China

University of Chinese Academy of Sciences, Beijing, PR China

Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, P. R. China

Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, P. R. China;7. School of Human and Social Sciences, University of West London, London, UK

Abstract:
Keywords:adenosine A2A receptor (A2AR)  c-Fos  loss of consciousness (LOC)  propofol  resting-state functional magnetic resonance imaging (rsfMRI)
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