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CRISPR/Cas9-mediated grna gene knockout leads to neurodevelopmental defects and motor behavior changes in zebrafish
Authors:Jiuling Zhu  Huimin Xu  Hui Song  Xiang Li  Ning Wang  Junli Zhao  Xiaojing Zheng  Kwang-Youn Kim  Hui Zhang  Qinwen Mao  Haibin Xia
Affiliation:1. Laboratory of Gene Therapy, Department of Biochemistry, College of Life Sciences, Shaanxi Normal University, Xi’an, Shaanxi, P.R. China;2. Department of Preventive Medicine, Division of Biostatistics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA;3. Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
Abstract:
Keywords:CRISPR/Cas9  grn  knockout  PGRN  phenotype  zebrafish
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