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Free-living amoebae promote Candida auris survival and proliferation in water
Authors:F. Hubert  M.-H. Rodier  A. Minoza  V. Portet-Sulla  E. Cateau  K. Brunet
Affiliation:1. Faculté de Médecine et Pharmacie, Université de Poitiers, Poitiers, France

Département des agents infectieux, Service de Mycologie-Parasitologie, CHU Poitiers, Poitiers, France;2. Faculté de Médecine et Pharmacie, Université de Poitiers, Poitiers, France

Département des agents infectieux, Service de Mycologie-Parasitologie, CHU Poitiers, Poitiers, France

UMR CNRS 7267, Poitiers, France;3. Faculté de Médecine et Pharmacie, Université de Poitiers, Poitiers, France

Abstract:Candida auris is an emerging species responsible for life-threatening infections. Its ability to be resistant to most systemic antifungal classes and its capacity to persist in a hospital environment have led to health concerns. Currently, data about environmental reservoirs are limited but remain essential in control of C. auris spread. The aim of our study was to explore the interactions between C. auris and two free-living amoeba (FLA) species, Vermamoeba vermiformis and Acanthamoeba castellanii, potentially found in the same water environment. Candida auris was incubated with FLA trophozoites or their culture supernatants. The number of FLA and yeasts was determined at different times and transmission electron microscopy (TEM) was performed. Supernatants of FLAs promoted yeast survival and proliferation. Internalization of viable C. auris within both FLA species was also evidenced by TEM. A water environmental reservoir of C. auris can therefore be considered through FLAs and contamination of the hospital water networks would consequently be possible.
Keywords:environmental mycology  infection  pathogenesis  protozoa  yeasts
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