首页 | 本学科首页   官方微博 | 高级检索  
   检索      


PETER PHAN: An MRI phantom for the optimisation of radiomic studies of the female pelvis
Institution:1. Department of Oral and Maxillofacial Radiology, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka 565-0871, Japan;2. Department of Radiation Oncology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan;3. Department of Oral and Maxillofacial Radiology, Institute of Biomedical & Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan;1. Center for Advanced Medical Imaging Sciences, Division of Nuclear Medicine and Molecular Imaging, Department of Imaging, Massachusetts General Hospital, Boston, MA, USA;2. Department of Radiology, Harvard Medical School, Boston, MA, USA;3. Department of Medical Imaging, University of Arizona, Tucson, AZ, USA;1. Department of Radiology, Nationwide Children''s Hospital, 700 Children''s Drive, Columbus, OH 43205;2. Siemens Medical Solutions, Cleveland, Ohio;3. Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China;1. Service d''Imagerie Médicale, AP-HP, Hôpitaux Universitaires Henri Mondor, Créteil 94000, France;2. Faculté de Santé, Université Paris Est Créteil, Créteil 94000, France;3. INSERM IMRB, U 955, Equipe 18, Créteil 94000, France;4. Siemens Healthcare SAS, Saint-Denis 93200, France;5. MR Application Predevelopment, Siemens Healthcare GmbH, Erlangen 91058, Germany
Abstract:PurposeTo develop a phantom for methodological radiomic investigation on Magnetic Resonance (MR) images of female patients affected by pelvic cancer.MethodsA pelvis-shaped container was filled with a MnCl2 solution reproducing the relaxation times (T1, T2) of muscle surrounding pelvic malignancies. Inserts simulating multi-textured lesions were embedded in the phantom. The relaxation times of muscle and tumour were measured on an MR scanner on healthy volunteers and patients; T1 and T2 of MnCl2 solutions were evaluated with a relaxometer to find the concentrations providing a match to in vivo relaxation times. Radiomic features were extracted from the phantom inserts and the patients’ lesions. Their repeatability was assessed by multiple measurements.ResultsMuscle T1 and T2 were 1128 (806–1378) and 51 (40–65) ms, respectively. The phantom reproduced in vivo values within 13% (T1) and 12% (T2). T1 and T2 of tumour tissue were 1637 (1396–2121) and 94 (79–101) ms, respectively. The phantom insert best mimicking the tumour agreed within 7% (T1) and 24% (T2) with in vivo values. Out of 1034 features, 75% (95%) had interclass correlation coefficient greater than 0.9 on T1 (T2)-weighted images, reducing to 33% (25%) if the phantom was repositioned. The most repeatable features on phantom showed values in agreement with the features extracted from patients’ lesions.ConclusionsWe developed an MR phantom with inserts mimicking both relaxation times and texture of pelvic tumours. As exemplified with repeatability assessment, such phantom is useful to investigate features robustness and optimise the radiomic workflow on pelvic MR images.
Keywords:Radiomics  Magnetic resonance imaging (MRI)  Texture  Radiomic phantom  Repeatability
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号