A comparative dosimetry study of an alanine dosimeter with a PTW PinPoint chamber at ultra-high dose rates of synchrotron radiation |
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| Institution: | 1. National Center for Radiation Research and Technology (NCRRT), Atomic Energy Authority (AEA), P.O. Box 8029, Nasr City, Cairo 11787, Egypt;2. ESRF-The European Synchrotron, ID17 Biomedical beamline, 71 Avenue des Martyrs, 38000 Grenoble, France;3. UA7 STROBE Inserm, Grenoble Alpes University, Grenoble, France;4. Swansea University Medical School, Singleton Park, Swansea SA2 8PP, United Kingdom;1. Department of Physics, University of Oslo, P.O. Box 1048 Blindern, N-0316 Oslo, Norway;2. Department of Medical Physics, Oslo University Hospital, P.O. Box 4953 Nydalen, N-0424 Oslo, Norway;3. Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, P.O. Box 8905, N-7491 Trondheim, Norway;4. Department of Radiation Oncology (MAASTRO), GROW – School for Oncology and Developmental Biology, Maastricht University Medical Center, P.O. Box 616, 6200 MD Maastricht, the Netherlands;1. Radiation Protection and Dosimetry Department, National Center for Radiation Research and Technology (NCRRT), Atomic Energy Authority (AEA), P.O. Box 8029, 3-Ahmad El-Zomor St., Nasr City, Cairo, Egypt;2. Chemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt;1. Radiation Technology Center, Atomic Energy Research Institute, King Abdulaziz City for Science and Technology, P.O. Box 6086, Riyadh, 11442, Saudi Arabia;2. Biomedical Physics Department, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia;3. Polymer Chemistry Department, National Center for Radiation Research and Technology, Atomic Energy Authority, PO Box 8029, Nasr City, Cairo, Egypt;4. Radiation Protection and Dosimetry Department, National Center for Radiation Research and Technology, Atomic Energy Authority, PO Box 8029, Nasr City, Cairo, Egypt;1. Radiation Protection and Dosimetry Department, National Center for Radiation Research and Technology, Atomic Energy Authority (AEA), P.O. Box 8029, Nasr City, Cairo, Egypt;2. Physics Department, Faculty of Science, Al-Azhar University, Cairo, Egypt;3. ESRF-The European Synchrotron, 71, Avenue des Martyrs, Grenoble, France |
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| Abstract: | The use of synchrotron X-ray sources provides innovative approaches in radiation therapy. The unique possibility to generate quasi-parallel beams promoted the development of microbeam radiation therapy (MRT), an innovative approach able to reduce damages to normal tissues while delivering considerable doses in the lesion. Accurate dosimetry in broad-beam configuration (prior to the spatial fractionation of the incident X-ray fan) is very challenging at ultra-high dose rate synchrotron sources.The available reference dosimetry protocol based on the use of a PTW PinPoint ionization chamber was compared with alanine dosimetry at the European Synchrotron Radiation Facility (ESRF) ID17 Biomedical beamline, an orthovoltage X-ray source with an average dose rate of 11.6 kGy/s. Reference dose measurements of the alanine pellets were performed at the National Centre for Radiation Research and Technology (NCRRT) 60Co facility in Egypt. All alanine dosimeters were analysed by an electron paramagnetic resonance spectrometer.We determined a relative response rESRF = 0.932 ± 0.027 (1σ) of the alanine pellets irradiated at the ESRF compared to the 60Co facility. Considering the appropriate corrections for the ESRF polychromatic spectrum and the different field size used, our result is in agreement with the previous work of Waldeland et al. for which the utilised alanine contained the same amount of binder, and it is consistent with the works of Anton et al. and Butler et al. for which the utilised alanine contained a higher amount of binder.We confirm that alanine is an appropriate dosimeter for ultra-high dose rate calibration of orthovoltage X-ray sources. |
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| Keywords: | Alanine dosimeter Ionization chamber X-ray radiation therapy Dosimetry at ultra-high dose rate Dosimetry for orthovoltage X-rays |
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