CdTe compact gamma camera for coded aperture imaging in radioguided surgery |
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| Institution: | 1. Universita’ di Napoli Federico II, Dipartimento di Fisica “Ettore Pancini”, I-80126 Napoli, Italy;2. INFN Sezione di Napoli, I-80126 Napoli, Italy;3. Elettra-Sincrotrone Trieste S.C.p.A., Trieste, Italy;4. Azienda Ospedaliera Universitaria, Ospedali Riuniti, Foggia, Italy;1. Korea Atomic Energy Research Institute, Dukjin-dong, Yuseong-gu, Daejeon 305-303, Republic of Korea;2. Department of Nuclear Engineering, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 133-791, Republic of Korea;1. Università di Napoli Federico II, Dipartimento di Fisica, Via Cintia, Naples I-80126, Italy;2. INFN Sezione di Napoli, Via Cintia, Naples I-80126, Italy;3. Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche, Via Tommaso De Amicis, 95, Naples I-80145, Italy;4. Università di Napoli Federico II, Dipartimento di Scienze Biomediche Avanzate, Via Pansini, 5, Naples I-80131, Italy;1. Department of Surgery, University of Virginia, Charlottesville, Virginia;2. Department of Physics, University of Virginia, Charlottesville, Virginia;3. Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia;4. Physics Division, Radiation Detector and Imaging Group, Thomas Jefferson National Accelerator Facility, Newport News, Virginia;5. Department of Radiology, West Virginia University, Morgantown, West Virginia;6. Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, Virginia;7. Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia;1. Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran;2. Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran;3. Chronic Respiratory Disease Research Center, NRITLD, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran;4. PET/CT and Cyclotron Center, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran;5. Massachusetts General Hospital, Harvard Medical School, Boston, USA;1. Space Research Centre, University of Leicester, Leicester LE1 7RH, UK;2. Clinical Imaging Group, Sandwell and West Birmingham NHS Hospital Trust, West Bromwich B71 4HJ, UK;3. Radiological and Imaging Sciences, School of Medicine, University of Nottingham, Nottingham NG7 2UH, UK |
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| Abstract: | The aim of this work was to assess the performance of a prototype compact gamma camera (MediPROBE) based on a CdTe semiconductor hybrid pixel detector, for coded aperture imaging. This probe can be adopted for various tasks in nuclear medicine such as preoperative sentinel lymph node localization, breast imaging with 99mTc radiotracers and thyroid imaging, and in general in radioguided surgery tasks. The hybrid detector is an assembly of a 1-mm thick CdTe semiconductor detector bump-bonded to a photon-counting CMOS readout circuit of the Medipix2 series or energy-sensitive Timepix detector. MediPROBE was equipped with a set of two coded aperture masks with 0.07-mm or 0.08-mm diameter holes. We performed laboratory measurements of field of view, system spatial resolution, and signal-difference-to-noise ratio, by using gamma-emitting radioactive sources (109Cd, 125I, 241Am, 99mTc). The system spatial resolution in the lateral direction was 0.56 mm FWHM (coded aperture mask with holes of 0.08 mm and a 60 keV source) at a source-collimator distance of 50 mm and a field of view of 40 mm by side. Correspondingly, the longitudinal resolution in 3D source localization tasks was about 3 mm. MediPROBE showed a significant improvement in terms of spatial resolution when equipped with the high-resolution coded apertures, with respect to the performance previously reported with 1–2 mm pinhole apertures as well as with respect to adopting a 0.35 mm pinhole aperture. |
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| Keywords: | Compact gamma camera CdTe Coded aperture Radioguided surgery Medipix2 Timepix |
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