Affiliation: | 1. Catalysis Research and Application Center, İnönü University, Malatya, Turkey Drug Application and Research Center, İnönü University, Malatya, Turkey;2. Tokat Vocational School of Health Services, Department of Medical Services and Techniques, Gaziosmanpasa University, Tokat, Turkey;3. Catalysis Research and Application Center, İnönü University, Malatya, Turkey Drug Application and Research Center, İnönü University, Malatya, Turkey Department of Chemistry, Faculty of Science and Art, İnönü University, Malatya, Turkey;4. Catalysis Research and Application Center, İnönü University, Malatya, Turkey;5. Department of Chemistry, Faculty of Sciences, Ataturk University, Erzurum, Turkey |
Abstract: | A series of vinyl functionalized 5,6-dimethylbenzimidazolium salts are synthesized. All compounds were fully characterized by elemental analyses, MS, 1H-NMR, 13C-NMR, and IR spectroscopy techniques. Enzyme inhibition is a very active area of research in drug design and development. In this study, the synthesized novel benzimidazolium salts were evaluated toward the human erythrocyte carbonic anhydrase I (hCA I), and II (hCA II) isoenzymes, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. They demonstrated highly potent inhibition ability against hCA I with Ki values of 484.8 ± 62.6–1389.7 ± 243.2 nM, hCA II with Ki values of 298.9 ± 55.7–926.1 ± 330.0 nM, α-glycosidase with Ki values of 170.3 ± 27–760.1 ± 269 μM, AChE with Ki values of 27.1 ± 3–77.6 ± 1.7 nM, and BChE with Ki values of 21.0 ± 5–61.3 ± 15 nM. As a result, novel vinyl functionalized 5,6-dimethylbenzimidazolium salts (1a–g) exhibited effective inhibition profiles toward studied metabolic enzymes. Therefore, we believe that these results may contribute to the development of new drugs particularly to treat some global disorders including glaucoma, Alzheimer's disease, and diabetes. |