LEP and LEPR are possibly a double-edged sword for wound healing |
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| Authors: | Kai-Wen Zhang Yuan Jia Yue-Yue Li Dan-Yang Guo Xiao-Xiao Li Kai Hu Xiao-Xi Qian Zhong-Hua Chen Jun-Jie Wu Zheng-Dong Yuan Feng-Lai Yuan |
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| Affiliation: | 1. Department of Medicine, Institute of Integrated Traditional Chinese and Western Medicine, Wuxi Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Traditional Chinese Medicine, Wuxi, China;2. Affiliated Hospital of Jiangnan University, Wuxi, China;3. Department of Medicine, The Nantong University, Nantong, China;4. Institute of Integrated Chinese and Western Medicine, The Hospital Affiliated to Jiangnan University, Wuxi, China |
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| Abstract: | Wound healing is a complex and error-prone process. Wound healing in adults often leads to the formation of scars, a type of fibrotic tissue that lacks skin appendages. Hypertrophic scars and keloids can also form when the wound-healing process goes wrong. Leptin (Lep) and leptin receptors (LepRs) have recently been shown to affect multiple stages of wound healing. This effect, however, is paradoxical for scarless wound healing. On the one hand, Lep exerts pro-inflammatory and profibrotic effects; on the other hand, Lep can regulate hair follicle growth. This paper summarises the role of Lep and LepRs on cells in different stages of wound healing, briefly introduces the process of wound healing and Lep and LepRs, and examines the possibility of promoting scarless wound healing through spatiotemporal, systemic, and local regulation of Lep levels and the binding of Lep and LepRs. |
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| Keywords: | leptin leptin receptor scar skin wound healing |
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