Short-duration dynamic FDG PET imaging: Optimization and clinical application

PurposeWe aimed to investigate whether short dynamic PET imaging started at injection, complemented with routine clinical acquisition at 60-min post-injection (static), can achieve reliable kinetic analysis.MethodsDynamic and static 18F-2-fluoro-2-deoxy-D-glucose (FDG) PET data were generated using realistic simulations to assess uncertainties due to statistical noise as well as bias. Following image reconstructions, kinetic parameters obtained from a 2-tissue-compartmental model (2TCM) were estimated, making use of the static image, and the time duration of dynamic PET data were incrementally shortened. We also investigated, in the first 2-min, different frame sampling rates, towards optimized dynamic PET imaging. Kinetic parameters from shortened dynamic datasets were additionally estimated for 9 patients (15 scans) with liver metastases of colorectal cancer, and were compared with those derived from full dynamic imaging using correlation and Passing–Bablok regression analyses.ResultsThe results showed that by reduction of dynamic scan times from 60-min to as short as 5-min, while using static data at 60-min post-injection, bias and variability stayed comparable in estimated kinetic parameters. Early frame samplings of 5, 24 and 30 s yielded highest biases compared to other schemes. An early frame sampling of 10 s generally kept both bias and variability to a minimum. In clinical studies, strong correlation (r ≥ 0.97, P < 0.0001) existed between all kinetic parameters in full vs. shortened scan protocols.ConclusionsShortened 5-min dynamic scan, sampled as 12 × 10 + 6 × 30 s, followed by 3-min static image at 60-min post-injection, enables accurate and robust estimation of 2TCM parameters, while enabling generation of SUV estimates.